Due to a successful vaccination campaign, Smallpox is one of the few diseases to have been eradicated. It was an infectious disease caused by one of two virus variants, Variola major and Variola minor and the risk of death following contracting the disease was about 30%, with higher rates among babies. The last naturally occurring case was diagnosed in 1977 and the World Health Organization certified the global eradication of the disease in 1980.
CJD is a fatal brain disorder caused by an infectious protein which can be transmitted by contaminated harvested human brain products, corneal grafts, dural grafts, or electrode implants and human growth hormone. Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances in the early stages and dementia, involuntary movements, blindness, weakness, and coma in the latter ones. About 90% of people die within a year of diagnosis.